Principal Scientist, Preclinical Biomarker Expert - Boehringer Ingelheim (Willimantic)


: $101,200.00 - $151,450.00 /year *

Employment Type

: Full-Time


: Scientific Research

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Boehringer Ingelheimis currently seeking a driven and innovativePrincipal Scientist to join our Non-clinical Drug Safety (NDS) Department at ourRidgefield, CTfacility.

The Integrative Toxicology Group is currently recruiting a Laboratory Head to develop and characterizebiomarkers to support safety profiling of new therapeutic products (biologics, small molecules, oncolytic viruses and other novel modalities). The candidate will collaborate with our Modeling, Molecular Pathology, and Immunopharmacology core labs. Additionally, the incumbent will work in matrix with our Research, DMPK, and Translational Medicine departments, and will operate as primary technical monitor for outsourced studies.

Main tasks:

  • Demonstrates an expertise in a specific project-relevant area or technology (i.e. biomarker discovery/qualification, safety biomarker expertise).
  • Directs and oversees the experimental design and results of technicians and junior level scientists; has full accountability for direct reports, including but not limited to goal setting and definition of personal development plans
  • Supervises and reviews preparation of clear technical reports, publications and oral presentations. Independently communicate team results in the form of reports and or presentations; delivers updates to senior level management in context of overall project/lab goals
  • Propose new technologies and concepts in support of multiple projects; develops broad knowledge in field of expertise, including the ability to interpret current literature relevant to R&D projects, and visibility outside of functional area
  • Assumes departmental responsibility for projects in the Discovery phase and/or supports multiple project teams as subject matter expert
  • Complies with all applicable regulations; ensures that work performed in area of responsibility is conducted in a safe and compliant manner; maintains proper records in accordance with SOPs, appropriate guidance and policies
  • Contributes to departmental administration; demonstrates fiscal responsibility with respect to cost of experiments, technology, external collaborations, and travel
  • Required Education & Experience:

  • PhD degree or equivalent with 5+ years experience in the field(s) of Molecular & Cellular Biology, Biochemistry, Pharmacology, or similar area of study
  • Demonstrates broad knowledge in the field of safety biomarkers, TK/TD relationships
  • Experience with standard molecular biology and omics approaches for biomarker discovery preferred (i.e. discovery/utilization of small and large RNAs, proteins, metabolites, lipids, etc. as safety or PD/TD biomarkers)
  • Knowledgeable in the use of mass spectrometry and in particular LCMS techniques for both quantitative and qualitative analysis of biological macromolecules (peptides, proteins, lipids, etc.)
  • Appropriate level of understanding of applicable regulations
  • Ability to communicate effectively both orally and in writing in an interdisciplinary environment
  • Previous supervisory and matrix working experience highly preferred
  • Desired Experience, Skills and Abilities:

  • Advanced knowledge in the area of biomarker discovery, preferably within toxicology/safety biomarker approaches
  • Experience with patient-derived xenografts, syngeneic and xenograft rat tumor models and/orin vivooncology studies in companion animals a plus
  • General knowledge of molecular and cell biology, genomics and principles of virology required; hands-on experience with oncolytic viruses extremely desired
  • Experience in immune-oncology (e.g.ex vivophenotyping;in vivotumor microenvironment profiling) desired
  • Experience with mammalian cell culture techniques (primary cells and cell lines), with stable cell line development or integration of reporter gene constructs a plus
  • Familiarity with the use of data display platforms (e.g. GraphPad Prism, TIBCO Spotfire)
  • Familiarity with the drug development process and/or toxicology of advantage
  • Evidence of publication records a plus
  • Eligibility Requirements:

  • Must be legally authorized to work in the United States without restriction.
  • Must be willing to take a drug test and post-offer physical (if required)
  • Must be 18 years of age or older
  • Who We Are:

    At Boehringer Ingelheim we create value through innovation with one clear goal: to improve the lives of patients. We develop breakthrough therapies and innovative healthcare solutions in areas of unmet medical need for both humans and animals. As a family owned company we focus on long term performance.We are powered by 50.000 employees globally who nurture a diverse, collaborative and inclusive culture.Learning and development for all employees is key because your growth is our growth.

    Associated topics: biomedical, cytometry, health, immunohematology, industrial hygienist, injury, nephrology, patient, pharmacy, physiology * The salary listed in the header is an estimate based on salary data for similar jobs in the same area. Salary or compensation data found in the job description is accurate.

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